What Is VDR?

08 Oct What Is VDR?

VDR is a gene which encodes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene called rs2228570 (FokI polymorphism), is associated with decreased bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern as well as the temporal off-and-on occupancy of the VDRE between the two components. It is also modulated by chromosomal locations and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes are enriched with a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) is an archive of data and documents relevant to business, legal transactions or processes. Viewing, downloading and printing are all restricted. It makes use of central computers and an extranet which is a restricted access Internet connection, allowing users to log in at specific times.

VDRs are most commonly used by investment banks and businesses involved in mergers and acquisitions. They need a secure platform for sharing information with investors or buyers in a clear and transparent manner, and the process of due diligence may require large amounts of information. Life science companies also use VDRs for everything from clinical trial results to microsoft teams HIPAA documentation for compliance.